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You can buy Orlistat (Xenical/Alli) as an over-the-counter alternative to Wegovy in the UK.

However, Orlistat is a very different type of weight-loss medication, and research suggests it’s not as effective as Wegovy in supporting weight loss.

What’s the difference between Orlistat and Wegovy?

Wegovy and Orlistat are weight-loss medications approved for use in the UK. However, they are different medications with distinct dosing schedules, costs, and mechanisms of action on the body.

Orlistat is a lipase inhibitor. Lipases are gut enzymes that break down fat from food, enabling the gut to transport fat into the body to be burnt for energy or stored in our fat cells for later use.

Orlistat blocks lipases, preventing some of the dietary fat from our meals from being digested. This leads to fewer calories being absorbed, which can support weight loss.

Orlistat is a prescription medication produced by two pharmaceutical companies in the UK:

  • GlaxoSmithKline: Alli, 60 mg and available over the counter (no prescription)
  • Roche: Xenical, 120 mg and available with a prescription

Wegovy is a weight-loss jab manufactured by Novo Nordisk. It’s a weekly weight-loss injection with semaglutide as the active ingredient.

Semaglutide is a that helps reduce hunger and appetite, allowing you to eat fewer calories, lose weight, and manage your blood sugar levels.

Wegovy is approved in the UK for individuals living with obesity to help them eat fewer calories and lose weight.

How much do Wegovy and Orlistat cost?

The over-the-counter version of Orlistat will cost around £18 a month, so it’s a very affordable medication.

In comparison, buying Wegovy and the injectable pens required for four weeks from Second Nature will cost £229 a month, rising to £299.

Should I try Orlistat or Wegovy for weight loss?

Orlistat is an affordable medication that is generally well-tolerated. However, it’s less effective than Wegovy. Wegovy is twice as effective as Orlistat for weight loss after one year.

So, if you’re looking for the most affordable weight-loss pill you can purchase over the counter, then Orlistat could be an option.

However, if you have a higher budget and are looking for the most effective weight-loss injection in the UK, semaglutide is a better choice.

Wegovy’s not a magic pill

Semaglutide is designed as an additional tool for weight management and, in most cases, shouldn’t be considered a lifelong medication.

Instead, it should be used to help you kickstart your weight loss and healthy journey while you commit to living a healthier lifestyle.

Ideally, we’d be able to lose weight without medication and lifestyle changes would be enough to support weight loss in the long term.

We’d generally recommend trying Second Nature’s before considering a weight-loss jab.

Changing your habits is the most sustainable way to achieve long-term weight loss, and it’s also less expensive.

At Second Nature, we’ve been trusted by the NHS since 2017 to support people with type 2 diabetes and obesity to lose weight, manage their blood sugar levels, and lead healthier lifestyles for the long term.

In 2022, the NHS in the BMJ that compared the weight loss outcomes of five providers in the National Diabetes Prevention Programme.

Second Nature was more than twice as effective at supporting weight loss than the other four providers.

However, if you’ve decided to try semaglutide (when it’s available) but need support in making positive changes to your lifestyle, Second Nature could be an option for you. But it’s worth noting that we have strict eligibility criteria.

Second Nature has been able to provide you with certain information about it.

Frequently asked questions

If you’re new to weight loss treatments and want to learn more about them, we’re here to help.

How do weight loss tablets work?

Tablets like (the brand name for Orlistat) work by reducing the amount of fat your body absorbs. Ordinarily, fats are broken down during the digestion process by enzymes called lipases. Xenical prevents these enzymes from working effectively, limiting how much fat your body is able to absorb. The remaining, undigested fat is then excreted.

How do weight loss injections work?

In contrast to Xenical, weight loss injections (or pens) work by suppressing your appetite - particularly your appetite for fatty foods. Some weight loss injections also slow the digestion process down, making you feel fuller for longer. They’re simple to use - check out our for more information.

How effective are weight loss treatments?

Clinical trials have repeatedly demonstrated the effectiveness of both weight loss tablets and injections, particularly in combination with a healthy diet and lifestyle., participants using lost almost 15% of their body weight over a 15-month period.

How do I place an order?

Starting your weight loss journey is simple with IQ Doctor. To begin, click on a product and then hit the 'Start Consultation' button. The online consultation process is quick, simple and free; just complete the form and we’ll verify whether the medication is suitable for you or not. If it is, you can then place your order and receive it the very next day.

Send questions for information on the medication or order ideas for someone who wants to learn more about weight loss treatments.

What is type of weight loss treatment?

Weight loss treatments are divided into different categories:

Liraglushan® (Saxenda®) weight loss injections:

  • Liraglushan® is a type of pens designed to suppress the appetite for fatty foods. The injections are given twice a day (30 minutes apart) and are both designed to help you maintain a more balanced diet and lifestyle. Consult with your doctor or diabetes specialist if you have any questions or if you’re worried about the weight loss experience.
  • Orlistat is a brand-name weight loss product that contains the active ingredient Xenical. It is used to treat meal planks and skin cancers. It works by inhibiting the digestion of calories from fat.

Semaglutide (Ozempic®):

Semaglutide (Ozempic) weight loss injections are used to suppress the appetite for food. These products are used for the same reason as fat-reducing treatments, to help people on a lower fat budget eat less. They work by preventing the absorption of about 30% of fat, from being absorbed. This is essential for cells like the cells of the small intestines. IfSemaglutide isn’t effective, it may be used as a treatment option.

Omeprazole (Prilosec®):

Omeprazole (Prilosec®) weight loss injections are used to suppress the appetite for food. They work by blocking the absorption of about 30% of fat, from being absorbed, into the body. This is crucial for cells like the cells of the small intestines.

What are the side effects of weight loss products?

Common side effects include:

  • Diarrhea
  • Nausea
  • Vomiting
  • Headache
  • Abdominal pain
  • constipation

You should always consult your doctor or a weight loss treatment specialist before using any weight loss medication.

How can I reduce the risk of weight gain with weight loss?

You should be cautious about using Semaglutide (Ozempic) products, as they may cause a range of side effects. You can follow the instructions provided by your doctor or a weight loss injection specialist closely. As with any medication, you should discuss potential risks with your healthcare provider.

Carrying too much weight puts stress on your body which can lead to a variety of health issues.

By reducing the amount of fat cells in your body, you reduce the likelihood of getting very serious conditions such as heart disease, certain cancers, stroke, liver disease, type II diabetes, osteoarthritis and high blood pressure. Being overweight also affects the respiratory system, with side effects such as sleep apnoea and asthma.

If you are overweight or clinically obese then you may suffer from low self-esteem or lack self-confidence and therefore losing weight can help you to regain confidence, increase your self-esteem and lower the risk of depression. It also helps improve the ratio of good to bad cholesterol; reduce blood pressure and inhibit the progression to type II diabetes.

Weight loss can be a difficult and daunting prospect, however clinical studies have shown that those who use Xenical / Orlistat alongside dieting can achieve 50% more weight loss than dieting alone.

Some Handy Tips for a Successful Weight Loss Journey

  • Try to eat three regular meals a day.
  • Try using a smaller plate and putting your knife and fork down between mouthfuls to encourage you to eat more slowly.
  • Don't buy tempting foods- if it's not in the cupboard, you can't eat it!
  • Fill at least half your plate with vegetables and salad, eat smaller portions of meat and starchy food like potatoes and bread. This will reduce your calories but keep you feeling full.
  • Prepare healthy snacks in advance and keep in the fridge to prevent you being tempted by other unhealthy, ready available snacks like crisps, biscuits and chocolate. You can chop up vegetables such as carrots, celery and peppers to be used with a tasty low calorie dip like salsa (tomato with onion, chilli, lime and coriander) or tzatziki (yoghurt with cucumber, garlic and mint).
  • If you have a sweet tooth, perhaps some fresh fruit with sugar free jelly or yoghurt.
  • Have a clear goal of weight loss like a clothing size to work towards or to lose weight for a specific event and it will help your motivation.
  • Plan meals in advance by deciding what you will have, write a list and then shop for the ingredients.
  • Batch cooking can help you stay on track and avoid poor choices when busy.
  • Drink lots of water as this helps metabolism.
  • Move more each day by simply walking or participate in any form of exercise that you enjoy.

Above all,don't give up.If you blow it one day, put it behind you as tomorrow is another day! Your weight loss may stop and start but keep going and the outcome will be well worth it.

Achieve an Activity Capacity

Enhanced memory

By taking AGLoquins for the first time in 20 minutes on the Market on 14th September 20, can mean more memories from the past being present in your mind, your thoughts and feelings.

AGLoquins help you remember and process important information, known as ‘buri virus codes’. Each ‘ codes’ contains a unique sequence of nucleotides that trigger a reaction in your body called ‘herpes’. Once you have learned the ‘ codes’ you will be able to recall ‘the events’ occurring in your past and the ‘ memories’ remaining in your memories.

AGLoquins work by targeting the virus that causes herpes, thus helping you remember and recall the ‘ messages’ you had when you were first infected with the virus.

More peace of mind

When you stop taking AGLoquins you more fully feel your best, your mind is clearer and your heart is faster, your heart is stronger and your skin is much more sensitive. A GLUCOSPRESSANXIS works more like a day-to-day application and is so much more effective it is given a professional name as ‘day to day’ medication. AGLoquins are so effective at helping you manage a wide range of aGLO conditions, you may notice that you only have one side effect of taking them all.

Rediscoverability

When you stop taking AGLines you have this very moment of clarity and connection to your aGLO world.

You’ve probably noticed that weight loss medications are generally considered safe for extended use. But that said, some weight loss drugs can actually be dangerous for some people.

That’s because drugs that mimic hormones can actually be harmful for people who are overweight or obese. For instance, those with or those who take drugs to treat type 2 diabetes can also have unwanted weight changes or weight gain when used along with a medication.

We specialize in providing our over 1,000,000 customers with relevant product and condition information created by our professional editorial staff which includes our team of medical writers, medical practitioners, and health educators.

Why it’s a risky pill?

The drugs weight loss pills are not dangerous, they simply don’t work for everyone. In fact, some of them may even have other health risks that may make them unsafe.

The drugs also have side effects that could make them unsafe for people who are overweight. These include:

If you take a drug called sibutramine, you may be at risk of having side effects that can make it dangerous for you to take the drug. You also may be at risk of experiencing a dangerous reaction to that drug.

The side effects of sibutramine also can make it unsafe for people who are obese. If you take a drug called phentermine, you may be at risk of having side effects that can make it dangerous for you to take the drug.

Some drugs that mimic hormones also can be dangerous for people who are overweight or obese.

The combination of sibutramine and phentermine can make it unsafe for people who are obese.

What’s the FDA warning on Xenical?

The FDA’s warning is that the drug may cause serious health problems.

Some weight loss pills are not safe for people who are overweight and obese. That’s because these medications may not be effective for them. And while Xenical can be helpful for some people, it may not be safe for everyone.

If you’re taking an anti-obesity drug, you may be at risk of certain side effects that could make it unsafe for you to take the drug.

If you’re taking Xenical, it may be unsafe for you to take the drug. If you have any concerns about side effects of Xenical, talk to your doctor about using Xenical instead of the anti-obesity drug.

What’s the FDA warning on Zepbound?

And while Zepbound can be helpful for some people, it may not be safe for everyone.

If you have any concerns about side effects of Zepbound, talk to your doctor about using Zepbound instead of the anti-obesity drug.